A car driving off the end of a road – symbolising the human race hurtling towards an uncertain future of its own making.
The car driver is following the sat-nav (GPS) unquestioningly as the car drives off the edge of the precipice (which metaphorically signifies the collapse of civilisation).
The road in this cartoon symbolises the human race’s road into the future, while the car is a metaphor for the human race itself, accompanied by its technological ‘life support system’. The message is meant to be that if we’re not careful it will all end very badly. This isn’t an anti-technology or anti-progress cartoon by the way – it’s just a view of how things might go if we aren’t careful.